COX

Combinatorial therapies involving GSI compounds with other chemotherapy agents Given that dysregulated Notch signaling plays an ancillary role in many cancers that are primarily caused by malfunction of other signaling pathways and cell growth mechanisms, a promising approach is to combine GSI-based inhibition of Notch with other chemotherapeutic agents that target these other pathways

Combinatorial therapies involving GSI compounds with other chemotherapy agents Given that dysregulated Notch signaling plays an ancillary role in many cancers that are primarily caused by...